%0 Journal Article
%T α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
%V 7
%N 1
%P 221
%U https://doi.org/10.1186/s40478-019-0859-3
%X Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein propagate in cell culture models and in vivo in a prion-like manner. However, it is still not known why the same pathological protein targets different cell populations, propagates with different kinetics and leads to a variety of diseases (synucleinopathies) with distinct clinical features. The aggregation of the protein alpha-synuclein yields different conformational polymorphs called strains. These strains exhibit distinct biochemical, physical and structural features they are able to imprint to newly recruited alpha-synuclein. This had led to the view that the clinical heterogeneity observed in synucleinopathies might be due to distinct pathological alpha-synuclein strains.
%J Acta Neuropathologica Communications
%A Rey, Nolwen L.
%A Bousset, Luc
%A George, Sonia
%A Madaj, Zachary
%A Meyerdirk, Lindsay
%A Schulz, Emily
%A Steiner, Jennifer A.
%A Melki, Ronald
%A Brundin, Patrik
%D December 30, 2019
%K peer-reviewed