IMPRiND Project

IMPRiND Symposium @ AD/PD™ 2021

On March 12, 2021, from 12.00 to 13:30 CET, at the 15th International Conference on Alzheimer’s and Parkinson’s, AD/PD™ 2021, IMPRiND will organise a symposium entitled: "Pathways and Targets in Models of Seeded Aggregation". This live discussion will include presentations from six IMPRiND partners: DZNE (M. Jucker), UCAM (M. Bacioglu), Novartis (F. Elwood), UOXF (G. Tofaris), HLU (F. Sotty) and BRFAA (L. Stefanis).

Neurodegenerative session at the BRAIN Conference 2021

The Neurodegenerative session at the upcoming online #theBRAINconference on 4th-5 March 2021 will features Prof Anne Rosser, Dr Sarah Tabrizi, Prof Bart de Stooper (@DeStrooperLab IMPRiND partner VIB) and Dr John Hardy.

Check out the rest of the sessions here and register: https://bit.ly/31kg99Xbit.ly/31kg99X

Newly released publication in Cells

@imprind study shows that fixed tissue from Parkinson’s disease and incidental Lewy body disease seeds the aggregation of monomeric αSyn into fibrillar assemblies.Read the last publication from IMPRiND partner CNRS in the Special Issue Molecular and Cellular Mechanisms of Parkinson's Disease of Cells.

IMPRiND Coordinator awarded MRC Senior Clinical Fellowship

Congratulations to George Tofaris, IMPRiND coordinator, who has been awarded a prestigious MRC Senior Clinical Fellowship. He is using induced pluripotent stem cells (iPSC) derived from patients to model alpha-synuclein aggregation in human neurons, and genetic screens to decipher relevant pathways that target aggregated alpha-synuclein for destruction. This MRC Fellowship will allow George's team to continue their work on fundamental mechanisms that cause Parkinson's disease @The_MRC. This is also an example of how IMI funding promotes academic careers and further collaborations @imprind

To read more about it.

Erwan Bézard awarded one of the prestigious @ERC_Research Synergy Grants.

The laboratories of Erwan Bézard (Research Director INSERM; Institute of Neurodegenerative Disorders), Laurent Groc (Research Director CNRS ; Interdisciplinary Institute for Neuroscience), Laurent Cognet (Research Director CNRS ; Laboratoire photonique numérique et nanosciences) and Valentin Nägerl (Professor at University of Bordeaux ; Research Director CNRS ; Interdisciplinary Institute for Neuroscience) have been awarded the ERC Synergy Award 2020. The ENSEMBLE project aims at underpinning the molecular mechanisms of physiological and pathological brain function. This ambitious and innovative endeavor is based on their ability to develop new approaches in high-resolution microscopy at the service of a new conceptual framework in brain cell communication through the study of the extracellular space, the compartment into which specific disease-related (e.g. Abeta, Tau, Synuclein) or treatment-related (e.g. antobodies) proteins accumulate and/or pass through. Shedding light on these fundamental and clinically-relevant questions will thus provide new insights into basic disease mechanisms as well as new avenues for therapy, such as new strategies to achieve adequate delivery of active molecules in specific brain areas (e.g. immunoglobulins for immunotherapy that bear huge promise but fail so far to meet their endpoints). #ERCSyG

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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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