IMPRiND Project

Publishable summaries

IMPRiND produces annual publishable reports which describe the project achievements. They are public and and the latest can be downloaded by clicking on the links below.

Scientific publications

Publications in peer-reviewed journals, conference proceedings, book chapters and books.
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.
Stem Cell Reports (2019). doi:10.1016/j.stemcr.2018.12.007
Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors.
The EMBO Journal e99871 (2019). doi:10.15252/embj.201899871
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s disease.
bioRxiv 468892 (2018). doi:10.1101/468892
Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.
Scientific Reports 8, 10788 (2018). doi:10.1038/s41598-018-28856-2
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
ACS Chemical Neuroscience 9, 1276-1282 (2018). doi:10.1021/acschemneuro.8b00094
Tau Filaments and the Development of Positron Emission Tomography Tracers.
Frontiers in Neurology 9, (2018). doi:10.3389/fneur.2018.00070
Structures of filaments from Pick’s disease reveal a novel tau protein fold.
Nature 561, 137-140 (2018). doi:10.1038/s41586-018-0454-y
Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold.
Acta Neuropathologica 136, 699-708 (2018). doi:10.1007/s00401-018-1914-z
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson’s disease cohort versus Parkinson’s disease: 123I-FP-CIT IMAGING IN A P.A53T PD COHORT.
Movement Disorders 33, 1734-1739 (2018). doi:10.1002/mds.27451
Neurodegeneration and the ordered assembly of α-synuclein.
Cell and Tissue Research 373, 137-148 (2018). doi:10.1007/s00441-017-2706-9
A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease.
Journal of Parkinson’s Disease 7, 569-576 (2017). doi:10.3233/JPD-171176
Cryo-EM structures of tau filaments from Alzheimer’s disease.
Nature 547, 185-190 (2017). doi:10.1038/nature23002

Project Flyer

The IMPRiND project flyer describes the project at a glance. It is mainly intended as a printed product but its electronic version is available for download.

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking ( under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.