RESEARCH HIGHLIGHT - Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

IMPRIND Partner CNRS showed in this paper published in Biophysical Journal, that structurally distinct fibrillar alpha-synuclein (α-syn) polymorphs trigger either Parkinson’s disease or multiple system atrophy hallmarks in vivo. Their study demonstrated that distinct fibrillar α-syn polymorphs bind to and cluster differentially at the plasma membrane in both primary neuronal cultures and organotypic hippocampal slice cultures from wild-type mice. He demonstrates an α-syn fibrillar polymorph-dependent and concentration-dependent seeding within neurons. Altogether, this study demonstrates that distinct α-syn fibrillar polymorphs affect differently neuronal homeostasis.

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking ( under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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